Invention Grant
- Patent Title: Modulation of the RNA interference pathway
- Patent Title (中): 调节RNA干扰途径
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Application No.: US10852630Application Date: 2004-05-24
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Publication No.: US07709453B2Publication Date: 2010-05-04
- Inventor: Donna T. Ward , Andrew T. Watt
- Applicant: Donna T. Ward , Andrew T. Watt
- Applicant Address: US CA Carlsbad
- Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee: Isis Pharmaceuticals, Inc.
- Current Assignee Address: US CA Carlsbad
- Agency: Isis Pharmaceuticals, Inc. Patent Department
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/04
Abstract:
Compounds, compositions and methods are provided for modulating the RNAi pathway. The compositions comprise oligonucleotides, targeted to nucleic acid molecules encoding EIF2C2. Methods of using these compounds for modulation of RNA interference as well as EIF2C2 expression and for diagnosis and treatment of disease associated with expression of EIF2C2 are provided. Also provided are compounds, compositions and methods for modulating the expression of DDX36. The compositions comprise oligonucleotides, targeted to nucleic acid encoding DDX36. Methods of using these compounds for modulation of DDX36 expression and for diagnosis and treatment of diseases and conditions associated with expression of DDX36 are provided.
Public/Granted literature
- US20050037387A1 Modulation of the RNA interference pathway Public/Granted day:2005-02-17
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