Invention Grant
US07709456B2 Modulation of gene expression by oligomers targeted to chromosomal DNA
有权
通过靶向染色体DNA的寡聚体调节基因表达
- Patent Title: Modulation of gene expression by oligomers targeted to chromosomal DNA
- Patent Title (中): 通过靶向染色体DNA的寡聚体调节基因表达
-
Application No.: US11599566Application Date: 2006-11-13
-
Publication No.: US07709456B2Publication Date: 2010-05-04
- Inventor: David R. Corey , David S. Shames , Bethany A. Janowski , John D. Minna
- Applicant: David R. Corey , David S. Shames , Bethany A. Janowski , John D. Minna
- Applicant Address: US TX Austin
- Assignee: Board of Regents, The University of Texas System
- Current Assignee: Board of Regents, The University of Texas System
- Current Assignee Address: US TX Austin
- Agency: Fulbright & Jaworski
- Main IPC: A61K31/70
- IPC: A61K31/70 ; C07H21/04
Abstract:
Synthesis of a target transcript of a gene is selectively increased in a mammalian cell by contacting the cell with a polynucleotide oligomer of 12-28 bases complementary to a region within a target promoter of the gene under conditions whereby the oligomer selectively increases synthesis of the target transcript.
Public/Granted literature
- US20070111963A1 Modulation of gene expression by oligomers targeted to chromosomal DNA Public/Granted day:2007-05-17
Information query
