Invention Grant
US07709475B2 Selective inhibitors against Cdk4 and Cdk6 having aminothiazole skeleton
失效
具有氨基噻唑骨架的Cdk4和Cdk6选择性抑制剂
- Patent Title: Selective inhibitors against Cdk4 and Cdk6 having aminothiazole skeleton
- Patent Title (中): 具有氨基噻唑骨架的Cdk4和Cdk6选择性抑制剂
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Application No.: US11596735Application Date: 2005-05-19
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Publication No.: US07709475B2Publication Date: 2010-05-04
- Inventor: Yoshikazu Iwasawa , Jun Shibata , Tadashi Shimamura , Hideki Kurihara , Takashi Mita , Nobuhiko Kawanishi , Takashi Hashihayata , Mikako Kawamura , Takeshi Sagara , Sachie Arai , Hiroshi Hirai
- Applicant: Yoshikazu Iwasawa , Jun Shibata , Tadashi Shimamura , Hideki Kurihara , Takashi Mita , Nobuhiko Kawanishi , Takashi Hashihayata , Mikako Kawamura , Takeshi Sagara , Sachie Arai , Hiroshi Hirai
- Applicant Address: JP Tokyo
- Assignee: Banyu Pharmaceutical Co., Ltd.
- Current Assignee: Banyu Pharmaceutical Co., Ltd.
- Current Assignee Address: JP Tokyo
- Agent David A. Muthard
- Priority: JP2004-178974 20040521
- International Application: PCT/JP2005/009593 WO 20050519
- International Announcement: WO2006/008874 WO 20060126
- Main IPC: C07D417/12
- IPC: C07D417/12 ; A61K31/506 ; C07D417/14 ; C07D491/08

Abstract:
The present invention relates to a compound represented by Formula [I]: wherein X is O, S, NH or CH2; Y1, Y2, Y3, Y4 and Y5, which may be identical or different, are each CH or N; however, at least one of Y1, Y2, Y3, Y4 and Y5 is N; Z1 and Z2, which may be identical or different, are each CH or N; n is an integer from 1 to 3; R1 is a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aliphatic heterocyclic ring or an aromatic heterocyclic ring, or a bicyclic aliphatic saturated hydrocarbon group; R2 and R3, which may be identical or different, are each a hydrogen atom, a lower alkyl group, a lower alkenyl group, a C3-C8 cycloalkyl group, a C6-C10 aryl group, an aromatic heterocyclic ring, or the like; and R4 is a hydrogen atom, a lower alkyl group, a C3-C6 cycloalkyl group or the like, or a pharmaceutically acceptable salt or ester thereof, and a selective inhibitor against Cdk4 and/or Cdk6 or an anticancer agent containing the compound or a pharmaceutically acceptable salt or ester thereof.
Public/Granted literature
- US20080081811A1 Selective Inhibitors Against Cdk4 and Cdk6 Having Aminothiazole Skeleton Public/Granted day:2008-04-03
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