Invention Grant
- Patent Title: Chemical compounds
- Patent Title (中): 化合物
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Application No.: US10504936Application Date: 2003-02-17
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Publication No.: US07709500B2Publication Date: 2010-05-04
- Inventor: Lilian Alcaraz , Mark Furber , Mark Purdie , Brian Springthorpe
- Applicant: Lilian Alcaraz , Mark Furber , Mark Purdie , Brian Springthorpe
- Applicant Address: SE
- Assignee: AstraZeneca AB
- Current Assignee: AstraZeneca AB
- Current Assignee Address: SE
- Agency: Fish & Richardson P.C.
- Priority: SE0200465 20020218; SE0202673 20020909
- International Application: PCT/SE03/00258 WO 20030217
- International Announcement: WO03/068743 WO 20030821
- Main IPC: A61K31/445
- IPC: A61K31/445 ; C07D211/44 ; C07D41/02
Abstract:
The invention provides compounds of formula (I): wherein: X is CH2, O, S(O)2 or NR10; Y is a bond, CH2, NR35, CH2NH, CH2NHC(O), CH(OH), CH(NHCOR33), CH(NHSO2R34), CH2O or CH2S; Z is C(O), or when Y is a bond Z can also be S(O)2; R1 is optionally substituted aryl, optionally substituted heterocyclyl or C4-6 cycloalkyl fused to a benzene ring; and R2, R3, R4, R5, R6, R7 and R8, R9, R10, R32, R33, R34 and R35 are as defined herein; are modulators of chemokine (especially CCR3) activity (for use in, for example, treating asthma). The invention also provides a process for making 4-(3,4-dichlorophenoxy)piperidine, which is useful as an intermediate for making certain compounds of the invention.
Public/Granted literature
- US20050107428A1 Chemical compounds Public/Granted day:2005-05-19
Information query
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