Invention Grant
US07709510B2 Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
失效
作为丙二酰辅酶A脱羧酶抑制剂的唑类可用作代谢调节剂
- Patent Title: Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
- Patent Title (中): 作为丙二酰辅酶A脱羧酶抑制剂的唑类可用作代谢调节剂
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Application No.: US10468379Application Date: 2002-02-19
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Publication No.: US07709510B2Publication Date: 2010-05-04
- Inventor: Thomas Arrhenius , Jie Fei Cheng , Mark E. Wilson , Rossy Serafimov , Alex M. Nadzan , Gary D. Lopaschuk , Jason R. Dyck
- Applicant: Thomas Arrhenius , Jie Fei Cheng , Mark E. Wilson , Rossy Serafimov , Alex M. Nadzan , Gary D. Lopaschuk , Jason R. Dyck
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- International Application: PCT/US02/04777 WO 20020219
- International Announcement: WO02/066035 WO 20020829
- Main IPC: A61K31/425
- IPC: A61K31/425 ; C07D277/00 ; C07D277/62
Abstract:
The present invention relates to methods of treatment of certain metabolic diseases, and to novel compounds and their prodrugs, and/or pharmaceutically acceptable salts, pharmaceutical compositions containing such compounds useful in treating such diseases. In particular, this invention relates to the use of novel compounds and compositions for treatment of cardiovascular diseases, diabetes, cancers, acidosis, and obesity through the inhibition of malonyl-CoA decarboxylase (MCD). These compounds have the formulae (I) and (II), wherein Y, C, R1, R2, R6, and R7 are defined herein.
Public/Granted literature
- US20040092503A1 Azoles as malonyl-coa decarboxylase inhibitors useful as metabolic modulators Public/Granted day:2004-05-13
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