Invention Grant
US07709600B2 Interaction between the VHL tumor suppressor and hypoxia inducible factor, and assay methods relating thereto
有权
VHL肿瘤抑制因子和缺氧诱导因子之间的相互作用以及与之相关的测定方法
- Patent Title: Interaction between the VHL tumor suppressor and hypoxia inducible factor, and assay methods relating thereto
- Patent Title (中): VHL肿瘤抑制因子和缺氧诱导因子之间的相互作用以及与之相关的测定方法
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Application No.: US10901583Application Date: 2004-07-29
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Publication No.: US07709600B2Publication Date: 2010-05-04
- Inventor: Peter John Ratcliffe , Patrick Henry Maxwell , Christopher William Pugh
- Applicant: Peter John Ratcliffe , Patrick Henry Maxwell , Christopher William Pugh
- Applicant Address: GB
- Assignee: Isis Innovation Limited
- Current Assignee: Isis Innovation Limited
- Current Assignee Address: GB
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner LLP
- Priority: GB9911047.0 19990512
- Main IPC: C07K5/00
- IPC: C07K5/00

Abstract:
The invention relates to the finding that the VHL tumour suppressor protein regulates hypoxia inducible factor α subunits, by targeting HIF α for destruction in normoxic, but not hypoxic cells. The invention provides assays for modulators of this interaction, and peptides based upon HIF α subunit sequences which may modulate this interaction.
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