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Invention Grant
US07709625B2 Methods and compositions for bone marrow stem cell-derived macrophage delivery of genes for gene therapy 失效
用于基因治疗的基因的骨髓干细胞来源的巨噬细胞递送的方法和组合物

Methods and compositions for bone marrow stem cell-derived macrophage delivery of genes for gene therapy
Abstract:
The present invention provides an isolated nucleic acid comprising a promoter operably linked to a nucleic acid encoding a peptide or protein and/or an RNA (e.g., antisense or ribozyme), wherein the promoter comprises elements that can include, but are not limited to, a) a myeloid specific promoter element comprising a core sequence GAGGAA; b) a myeloid specific promoter element comprising a core sequence AAGGAGAAG; c) a myeloid specific promoter element comprising a core sequence TTTCCAAA; d) a myeloid specific promoter element comprising a core sequence TGTGGTTGC; e) a myeloid specific promoter element comprising a core sequence TGAGTCA; f) a myeloid associated promoter element comprising a core sequence CCGCCC; and g) any combination of (a), (b), (c), (d), (e) and/or (f), any combination of multiples of (a), (b), (c), (d), (e) and/or (f), in any order and/or in any orientation (forward or reverse).
Abstract(Chinese):

本发明提供了分离的核酸，其包含与编码肽或蛋白质和/或RNA（例如，反义或核酶）的核酸可操作地连接的启动子，其中启动子包含可以包括但不限于， a）包含核心序列GAGGAA的骨髓特异性启动子元件; b）骨髓特异性启动子元件，其包含核心序列AAGGAGAAG; c）包含核心序列TTTCCAAA的骨髓特异性启动子元件; d）包含核心序列TGTGGTTGC的骨髓特异性启动子元件; e）包含核心序列TGAGTCA的骨髓特异性启动子元件; f）包含核心序列CCGCCC的骨髓相关启动子元件; （a），（b），（c），（c），（d），（e）和/或（f））的任何组合，（a），（b） d），（e）和/或（f），以任何顺序和/或任何方向（正向或反向）。

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