Invention Grant
US07709644B2 Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane
失效
顺式-8-苄基-7,9-二氧代-2,8-二氮杂双环[4.3.0]壬烷对映异构体富集方法
![Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane](/docs/US/2010-05-04/US07709644B2/abs.jpg.600x600.jpg)
- Patent Title: Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane
- Patent Title (中): 顺式-8-苄基-7,9-二氧代-2,8-二氮杂双环[4.3.0]壬烷对映异构体富集方法
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Application No.: US11651309Application Date: 2007-01-09
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Publication No.: US07709644B2Publication Date: 2010-05-04
- Inventor: Herbert Diehl , Andreas Krebs , Walter Lange , Hanns-Ingolf Paul , Dietrich Seidel , Rolf Grosser , Tobias Reichelt
- Applicant: Herbert Diehl , Andreas Krebs , Elvira Krebs, legal representative , Walter Lange , Hanns-Ingolf Paul , Dietrich Seidel , Rolf Grosser , Tobias Reichelt
- Applicant Address: DE Leverkusen
- Assignee: LANXESS Deutschland GmbH
- Current Assignee: LANXESS Deutschland GmbH
- Current Assignee Address: DE Leverkusen
- Agent Michael A. Miller
- Priority: DE10226923 20020617
- Main IPC: C07D487/04
- IPC: C07D487/04
![Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane](/abs-image/US/2010/05/04/US07709644B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to a process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane with the aid of continuous countercurrent chromatography, which is also described as SMB chromatography (SMB=simulated moving bed).In a further aspect, the invention relates to a process for the preparation of (1S,6R)-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane using the aforementioned process, which furthermore includes a racemization step.
Public/Granted literature
- US20070213536A1 Process for the enantiomeric enrichment of cis-8-benzyl-7,9-dioxo-2,8-diazabicyclo[4.3.0]nonane Public/Granted day:2007-09-13
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