Invention Grant
US07709678B2 Method for producing asymmetric alkyl compound using alkali-treated solid support, and alkali-treated solid support used in this method
失效
使用碱处理的固体支持体制备不对称烷基化合物的方法和用于该方法的碱处理的固体支持物
- Patent Title: Method for producing asymmetric alkyl compound using alkali-treated solid support, and alkali-treated solid support used in this method
- Patent Title (中): 使用碱处理的固体支持体制备不对称烷基化合物的方法和用于该方法的碱处理的固体支持物
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Application No.: US10576682Application Date: 2004-05-28
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Publication No.: US07709678B2Publication Date: 2010-05-04
- Inventor: Hideko Koshima , Haitao Yu
- Applicant: Hideko Koshima , Haitao Yu
- Applicant Address: JP
- Assignee: Japan Science and Technology Agency
- Current Assignee: Japan Science and Technology Agency
- Current Assignee Address: JP
- Agency: Sheridan Ross P.C.
- Priority: JP2003-364982 20031024
- International Application: PCT/JP2004/007393 WO 20040528
- International Announcement: WO2005/040096 WO 20050506
- Main IPC: C07C229/00
- IPC: C07C229/00 ; C07C211/00

Abstract:
An asymmetric alkyl compound producing method of the present invention includes a synthesizing step of carrying out an asymmetric synthesis reaction by mixing (i) a reaction solution containing a glycine imine ester, an alkyl halide, and an asymmetric catalyst having a catalytic action which causes the asymmetric synthesis reaction to proceed with (ii) an alkali-treated solid support obtained by treating with an alkaline substance a solid support made of an inorganic compound. By placing this mixture at room temperature, the asymmetric alkylation occurs between the glycine imine ester and the alkyl halide which are catalyzed by the asymmetric catalyst in an alkali-treated solid support contained in the mixture, and the asymmetric alkylation is completed in about 1 hour. Thus, a highly optically pure asymmetric alkyl compound can be obtained in high yield. Therefore, it is possible to provide the asymmetric alkyl compound producing method which does not require the agitation of the solvent, completes the asymmetric alkylation efficiently and stably in a short time, and synthesizes a highly optically pure asymmetric alkyl compound in high yield.
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