The invention discloses a method for reducing service loss in interworking between SS7 signaling network and M3UA. In the method, when state of an M3UA ASP-related signaling point changes, the SS7 signaling network may be notified by using messages defined in existing protocols or other messages. Thus, when performing service interworking with M3UA, the SS7 signaling network determines whether service interaction may be performed with M3UA in accordance with the state of current ASP-related signaling point. If the current ASP-related signaling point is unavailable, the SS7 signaling network will not perform service interaction. As a result, the service loss in interworking between SS7 signaling network and M3UA may be reduced without any affect on the normal service interworking between SS7 signaling network and M3UA. In addition, the method may conform to existing protocol standards, and implemented in a simple and easy way.