Invention Grant
US07713526B2 Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
有权
Wnt和卷曲受体作为头颈部鳞状细胞癌免疫治疗的靶标
- Patent Title: Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
- Patent Title (中): Wnt和卷曲受体作为头颈部鳞状细胞癌免疫治疗的靶标
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Application No.: US10285976Application Date: 2002-11-01
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Publication No.: US07713526B2Publication Date: 2010-05-11
- Inventor: Chae-Seo Rhee , Malini Sen , Christina Wu , Lorenzo M. Leoni , Maripat Corr , Dennis A. Carson
- Applicant: Chae-Seo Rhee , Malini Sen , Christina Wu , Lorenzo M. Leoni , Maripat Corr , Dennis A. Carson
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: McDermott Will & Emery LLP
- Main IPC: A61K39/395
- IPC: A61K39/395
Abstract:
The diverse receptor-ligand pairs of the Wnt and frizzled (Fzd) families play important roles during embryonic development, and thus may be overexpressed in cancers that arise from immature cells. The mRNA levels and expression levels of 5 Wnt (Wnt-1, 5a, 7a, 10b, 13) and 2 Fzd (Fzd-2, 5) genes in 10 head and neck squamous carcinoma cell lines (HNSCC) were investigated. In addition, anti-Wnt-1 antibodies were used to study the Wnt/Fzd signalling pathway. These results indicate that HNSCC cell lines overexpress one or more Wnt and Fzd genes, and the proliferation and survival of a subset of HNSCC may depend on the Wnt/Fzd pathway. Therefore, the Wnt and Fzd receptors may be useful targets for immunotherapy of this common cancer.
Public/Granted literature
- US20030165500A1 Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas Public/Granted day:2003-09-04
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