Invention Grant
US07713979B2 Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
失效
环烷基内酰胺衍生物作为11-β-羟基类固醇脱氢酶1的抑制剂
- Patent Title: Cycloalkyl lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
- Patent Title (中): 环烷基内酰胺衍生物作为11-β-羟基类固醇脱氢酶1的抑制剂
-
Application No.: US11718111Application Date: 2005-10-26
-
Publication No.: US07713979B2Publication Date: 2010-05-11
- Inventor: Thomas Daniel Aicher , Mark Joseph Chicarelli , Ronald Jay Hinklin , Hongqi Tian , Owen Brendan Wallace , John Gordon Allen , Zhaogen Chen , Thomas Edward Mabry , Jefferson Ray McCowan , Nancy June Snyder , Leonard Larry Winneroski, Jr.
- Applicant: Thomas Daniel Aicher , Mark Joseph Chicarelli , Ronald Jay Hinklin , Hongqi Tian , Owen Brendan Wallace , John Gordon Allen , Zhaogen Chen , Thomas Edward Mabry , Jefferson Ray McCowan , Nancy June Snyder , Leonard Larry Winneroski, Jr.
- Applicant Address: US IN Indianapolis
- Assignee: Eli Lilly and Company
- Current Assignee: Eli Lilly and Company
- Current Assignee Address: US IN Indianapolis
- Agent Dan L. Wood
- International Application: PCT/US2005/038369 WO 20051026
- International Announcement: WO2006/049952 WO 20060511
- Main IPC: C07D207/00
- IPC: C07D207/00 ; A61K31/40 ; A61K31/497 ; A61K31/445 ; C07D211/06 ; C07D403/00
Abstract:
The present invention discloses compounds of Formula I: (I) having 11beta-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as the use of the Formula I and compositions as medicaments to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, Syndrome X, and other conditions associated with hyperglycemia.
Public/Granted literature
- US20080275043A1 Cycloalkyl Lactam Derivatives as Inhibitors of 11-Beta-Hydroxysteroid Dehydrogenase 1 Public/Granted day:2008-11-06
Information query
