Invention Grant
- Patent Title: Targeting GLI proteins in human cancer by small molecules
- Patent Title (中): 通过小分子靶向人类癌症中的GLI蛋白
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Application No.: US11608197Application Date: 2006-12-07
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Publication No.: US07714014B2Publication Date: 2010-05-11
- Inventor: Biao He , Naoaki Fujii , Liang You , Zhidong Xu , David M. Jablons
- Applicant: Biao He , Naoaki Fujii , Liang You , Zhidong Xu , David M. Jablons
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Bozicevic, Field & Francis, LLP
- Agent Carol L. Francis
- Main IPC: A61K31/415
- IPC: A61K31/415 ; C07D231/06
Abstract:
This invention provides compositions, methods and kits for the diagnosis and treatment of cancers expressing a GLI polypeptide, and in particular a GLI1, GLI2 or GLI3 polypeptide. The invention provides small molecule compounds mimicking the transcriptional activation domain of a GLI polypeptide. The small molecule inhibitors of the invention specifically block the activator function of a GLI polypeptide, but not the repressor function of GLI3.
Public/Granted literature
- US20070149592A1 TARGETING GLI PROTEINS IN HUMAN CANCER BY SMALL MOLECULES Public/Granted day:2007-06-28
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