Invention Grant
US07714141B2 Processes for production of optically active PPAR-activating compounds and intermediates for production thereof
失效
用于制备光学活性PPAR活化化合物的方法及其生产用中间体
- Patent Title: Processes for production of optically active PPAR-activating compounds and intermediates for production thereof
- Patent Title (中): 用于制备光学活性PPAR活化化合物的方法及其生产用中间体
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Application No.: US11912811Application Date: 2006-05-30
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Publication No.: US07714141B2Publication Date: 2010-05-11
- Inventor: Yukiyoshi Yamazaki , Takaaki Araki , Minoru Koura , Kimiyuki Shibuya
- Applicant: Yukiyoshi Yamazaki , Takaaki Araki , Minoru Koura , Kimiyuki Shibuya
- Applicant Address: JP Nagoya-shi
- Assignee: Kowa Co., Ltd.
- Current Assignee: Kowa Co., Ltd.
- Current Assignee Address: JP Nagoya-shi
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: JP2005-159261 20050531; JP2005-176663 20050616
- International Application: PCT/JP2006/310755 WO 20060530
- International Announcement: WO2006/129649 WO 20061207
- Main IPC: C07D263/58
- IPC: C07D263/58 ; C07D277/82 ; C07D235/30

Abstract:
The invention provides a process for producing an optically active butyric acid compound and a production intermediate therefore at high yield and high purity.The present invention provides a process for producing Compound (6), including reacting Compound (1) with optically active 2-trifluoromethanesulfonyloxybutyrolactone (2a) in the presence of a base or reacting optically active 2-hydroxybutyrolactone (2b) under Mitsunobu reaction conditions, to thereby form Compound (3); reacting Compound (3) with an alcohol and a halogenating agent, to thereby form Compound (4); dehalogenating Compound (4), to thereby form Compound (5); and de-esterifying Compound (5).
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