Invention Grant
US07714141B2 Processes for production of optically active PPAR-activating compounds and intermediates for production thereof 失效
用于制备光学活性PPAR活化化合物的方法及其生产用中间体

Processes for production of optically active PPAR-activating compounds and intermediates for production thereof
Abstract:
The invention provides a process for producing an optically active butyric acid compound and a production intermediate therefore at high yield and high purity.The present invention provides a process for producing Compound (6), including reacting Compound (1) with optically active 2-trifluoromethanesulfonyloxybutyrolactone (2a) in the presence of a base or reacting optically active 2-hydroxybutyrolactone (2b) under Mitsunobu reaction conditions, to thereby form Compound (3); reacting Compound (3) with an alcohol and a halogenating agent, to thereby form Compound (4); dehalogenating Compound (4), to thereby form Compound (5); and de-esterifying Compound (5).
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