The present invention provides an intelligent mouse includes a physical environment conditions detector for sampling physical environment conditions in the intelligent mouse, a physical condition adjustor for adjusting the physical environment conditions; and a microprocessor unit for processing operations of the intelligent mouse. The microprocessor unit comprises a memory for storing a reference physical condition value represented a modest physical condition range; and an environment controller for processing the physical condition values and outputting a controlling command to the physical condition adjustor. The intelligent mouse can measure physical environment conditions automatically and adjust the physical environment conditions into a modest range automatically.