The invention provides a digital signage replacement module. The digital signage has a main circuit board and a plug-board disposed therein and connected to each other. The plug-board has a plug-card with a plug-slot, and a track disposed on each side thereof. The digital signage is covered up by a back cover so that an opening can be formed at one side edge of the digital signage. The computer module has a frame and a motherboard. The frame has a rail disposed on each side thereof and the motherboard has a slot and a connecting terminal disposed thereon. The slot has an interface socket card. The computer module can be placed into the digital signage through the opening with the rail placed into the track. Therefore, the connecting terminal is connected to the plug-slot and the computer module can be drawn out for maintenance.