In order, even in the case of bone screws with a particularly small head, to ensure a secure hold of the bone screw in a bone, a bone screw is proposed, having a screw body, which defines a longitudinal axis and is provided with a screw body external thread and has a proximal and a distal end, having a coupling element disposed on the proximal end for detachably connecting the screw body to a screw head designed substantially in the form of a U-shaped fork head with a coupling opening, wherein an edge of the coupling opening forms an axial stop for the coupling element for limiting a movement of the coupling element relative to the screw head in distal direction, wherein a maximum outside diameter of the screw body is larger than an inside diameter of the coupling opening, wherein the screw body comprises at least a first and a second screw body part. An osteosynthesis device having such a bone screw and a method of manufacturing such a bone screw are further proposed.