Invention Grant
- Patent Title: Anti-HGF/SF humanized antibody
- Patent Title (中): 抗HGF / SF人源化抗体
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Application No.: US11626055Application Date: 2007-01-23
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Publication No.: US07718174B2Publication Date: 2010-05-18
- Inventor: Junho Chung , Kisu Kim
- Applicant: Junho Chung , Kisu Kim
- Applicant Address: KR Seoul
- Assignee: Abxign, Inc.
- Current Assignee: Abxign, Inc.
- Current Assignee Address: KR Seoul
- Agency: Sughrue Mion, PLLC
- Priority: KR10-2006-0066241 20060714
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C12P21/08

Abstract:
The inventive anti-HGF/SF humanized antibody prepared by displaying on the surface of a phage an anti-HGF/SF chimeric Fab library comprising a set of human antibody light chain variable region (VL) and human antibody heavy chain variable region (VH) which are grafted with heavy chain complementary determining regions (HCDRs) of an anti-HGF/SF antibody of an animal other than human, has the equal or greater binding affinity than that of the parent anti-HGF/SF antibody, the neutralizing activity inhibiting the binding of HGF/SF to its receptor, cMET while having the reduced immunogenicity in human. Therefore, the inventive anti-HGF/SF humanized antibody can be used for preventing and treating diseases effectively, e.g., cancers, by the action of binding HGF/SF to cMET.
Public/Granted literature
- US20080038256A1 ANTI-HGF/SF HUMANIZED ANTIBODY AND METHOD FOR THE PREPARATION THEREOF Public/Granted day:2008-02-14
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