Invention Grant
US07718177B2 Antibodies directed to fragments of connective tissue growth factor (CTGF) polypeptide and methods and uses thereof
有权
针对结缔组织生长因子（CTGF）多肽的片段的抗体及其方法和用途
- Patent Title: Antibodies directed to fragments of connective tissue growth factor (CTGF) polypeptide and methods and uses thereof
- Patent Title (中): 针对结缔组织生长因子（CTGF）多肽的片段的抗体及其方法和用途
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Application No.: US10315568Application Date: 2002-12-09
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Publication No.: US07718177B2Publication Date: 2010-05-18
- Inventor: Gary R. Grotendorst
- Applicant: Gary R. Grotendorst
- Applicant Address: US FL Miami
- Assignee: University of Miami
- Current Assignee: University of Miami
- Current Assignee Address: US FL Miami
- Agency: DLA Piper LLP (US)
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/24 ; G01N33/53
Abstract:
The present invention is directed to CTGF fragments comprising at least exon 2 or exon 3 of CTGF and having the ability to induce extracellular matrix synthesis, in particular, collagen synthesis and myofibroblast differentiation. The present invention is further directed to methods using said CTGF fragments to identify compositions which modulate the activity of said CTGF fragments and to the compositions so identified. The invention also relates to methods of treating CTGF-associated disorders and diseases associated with the overproduction of the extracellular matrix.
Public/Granted literature
- US20030180300A1 Connective tissue growth factor fragments and methods and uses thereof Public/Granted day:2003-09-25
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