Invention Grant
US07718182B2 Polypeptides for inducing a protective immune response against Staphylococcus aureus
有权
用于诱导针对金黄色葡萄球菌的保护性免疫应答的多肽
- Patent Title: Polypeptides for inducing a protective immune response against Staphylococcus aureus
- Patent Title (中): 用于诱导针对金黄色葡萄球菌的保护性免疫应答的多肽
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Application No.: US11795538Application Date: 2006-01-17
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Publication No.: US07718182B2Publication Date: 2010-05-18
- Inventor: Rosemarie Kelly , Loren D. Schultz , Mark A. Miller , Mark D. Yeager , Tessie McNeely
- Applicant: Rosemarie Kelly , Loren D. Schultz , Mark A. Miller , Mark D. Yeager , Tessie McNeely
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Alysia A. Finnegan; Laura M. Ginkel; Sheldon O. Heber
- International Application: PCT/US2006/001665 WO 20060117
- International Announcement: WO2006/078680 WO 20060729
- Main IPC: A61K39/085
- IPC: A61K39/085 ; C12P21/04 ; C07H21/02 ; C07H21/04 ; C07K14/31
Abstract:
The present invention features polypeptides comprising an amino acid sequence structurally related to SEQ ID NO: 1 or a fragment thereof, S. aureus AhpC-AhpF compositions, and uses of such polypeptides and compositions. SEQ ID NO: 1 has a full length S. aureus AhpC sequence. A derivative of SEQ ID NO: 1 containing an amino His-tag and three additional carboxyl amino acids was found to produce a protective immune response against S. aureus. MGHHHHHHHHHHSSGHIEGRHMSLINKEILPFTAQAFDPKKDQFKEVTQE DLKGSWSVVCFYPADFSFVCPTELEDLQNQYEELQKLGVNVFSVSTDTHF VHKAWHDHSDAISKITYTMIGDPSQTITRNDVLDEATGLAQRGTFIIDPD GVVQASEINADGIGRDASTLAHKIKAAQYVRKNPGEVCPAKWEEGAKTLQ PGLDLVGKIAEQ
Public/Granted literature
- US20080131447A1 Polypeptides for Inducing a Protective Immune Response Against Staphylococcus Aureus Public/Granted day:2008-06-05
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