Invention Grant
- Patent Title: Substrates for TAFI (A)
- Patent Title (中): TAFI基板（A）
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Application No.: US10530165Application Date: 2002-12-06
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Publication No.: US07718406B2Publication Date: 2010-05-18
- Inventor: Hugo Ziegler , Dagmar Prasa , Jörg Stürzebecher , Peter Wikstroem
- Applicant: Hugo Ziegler , Dagmar Prasa , Jörg Stürzebecher , Peter Wikstroem
- Applicant Address: NL Heerlen
- Assignee: DSM IP Assets B.V.
- Current Assignee: DSM IP Assets B.V.
- Current Assignee Address: NL Heerlen
- Agency: Hoffman & Baron, LLP
- Priority: WOPCT/CH02/00553 20021004
- International Application: PCT/CH02/00670 WO 20021206
- International Announcement: WO2004/031216 WO 20040415
- Main IPC: C12P13/04
- IPC: C12P13/04 ; A61K38/00
Abstract:
The invention relates to compounds of general formula (I) and acid addition salts thereof, where the various symbols have the meanings given in the description and claims, the production and use thereof as substrate for the detection of TAFIa, a fibrinolysis inhibiting enzyme. The detection occurs by using the absorption between 400 and 412 nm, arising as a result of the formation of 3-carboxy-4-nitrothiophenol from Ellman's reagent as a function of time.
Public/Granted literature
- US20060068457A1 Substrates for tafi (a) Public/Granted day:2006-03-30
Information query
