Invention Grant
- Patent Title: IAP binding compounds
- Patent Title (中): IAP结合化合物
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Application No.: US10521723Application Date: 2003-07-15
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Publication No.: US07718600B2Publication Date: 2010-05-18
- Inventor: George McLendon , Rachael A. Kipp , Martin Case , Yigong Shi , Martin F. Semmelhack , Philip A. Albiniak , Aislyn D. Wist
- Applicant: George McLendon , Rachael A. Kipp , Martin Case , Yigong Shi , Martin F. Semmelhack , Philip A. Albiniak , Aislyn D. Wist
- Applicant Address: US NJ Princeton
- Assignee: The Trustees of Princeton University
- Current Assignee: The Trustees of Princeton University
- Current Assignee Address: US NJ Princeton
- Agency: Pepper Hamilton LLP
- International Application: PCT/US03/22071 WO 20030715
- International Announcement: WO2004/007529 WO 20040122
- Main IPC: C07K4/00
- IPC: C07K4/00 ; C07K5/00
Abstract:
Compounds that bind cellular IAPs (inhibitor of apoptosis proteins) are disclosed. The compounds are mimetics of the N-terminal tetrapeptide of IAP-binding proteins, such as Smac/DIABOLO, IIid, Grim and Reaper, which interact with a specific surface groove of IAP. Also disclosed are methods of using these compounds for therapeutic, diagnostic and assay purposes.
Public/Granted literature
- US20070032437A1 Iap binding compounds Public/Granted day:2007-02-08
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