Invention Grant
US07718644B2 Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
有权
抗心律失常药物和心力衰竭药物，针对兰诺定受体（RyR2）的泄漏及其应用
- Patent Title: Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
- Patent Title (中): 抗心律失常药物和心力衰竭药物，针对兰诺定受体（RyR2）的泄漏及其应用
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Application No.: US10809089Application Date: 2004-03-25
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Publication No.: US07718644B2Publication Date: 2010-05-18
- Inventor: Andrew Robert Marks , Donald W. Landry , Shixian Deng , Zhen Zhuang Cheng
- Applicant: Andrew Robert Marks , Donald W. Landry , Shixian Deng , Zhen Zhuang Cheng
- Applicant Address: US NY New York
- Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee: The Trustees of Columbia University in the City of New York
- Current Assignee Address: US NY New York
- Agency: Winston & Strawn LLP
- Main IPC: A01N43/00
- IPC: A01N43/00 ; A61K31/00
Abstract:
The present invention provides methods for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject. The present invention further provides methods for treating and preventing atrial and ventricular cardiac arrhythmias, heart failure, and exercise-induced sudden cardiac death in a subject. Additionally, the present invention provides use of JTV-519 in a method for limiting or preventing a decrease in the level of RyR2-bound FKBP12.6 in a subject who has, or is a candidate for, atrial fibrillation. Also provided are uses of 1,4-benzothiazepine derivatives in methods for treating and preventing atrial and ventricular cardiac arrhythmias and heart failure in a subject, and for preventing exercise-induced sudden cardiac death. The present invention also provides methods for identifying agents for use in treating and preventing atrial fibrillation and heart failure, and agents identified by these methods.
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