Invention Grant
US07718765B2 Methods of treating fibrosing diseases by induction of immune tolerance
有权
通过诱导免疫耐受治疗纤维化疾病的方法
- Patent Title: Methods of treating fibrosing diseases by induction of immune tolerance
- Patent Title (中): 通过诱导免疫耐受治疗纤维化疾病的方法
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Application No.: US11600525Application Date: 2006-11-16
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Publication No.: US07718765B2Publication Date: 2010-05-18
- Inventor: Arnold E. Postlethwaite , Andrew H. Kang
- Applicant: Arnold E. Postlethwaite , Andrew H. Kang
- Applicant Address: US TN Memphis
- Assignee: The University of Tennessee Research Foundation
- Current Assignee: The University of Tennessee Research Foundation
- Current Assignee Address: US TN Memphis
- Agency: Patton Boggs LLP
- Main IPC: C07K14/00
- IPC: C07K14/00 ; A61K38/00
Abstract:
The present invention has demonstrated for the first time that orally administered type I collagen (CI) induced tolerance to CI in patients suffering from systemic sclerosis (SSc) and ameliorated clinical manifestations of the disease. Accordingly, the present invention provides methods of treating a fibrosing disease by oral administration of a tissue protein, for example, collagen, derived from the tissue undergoing fibrosis.
Public/Granted literature
- US20070142286A1 Methods of treating fibrosing diseases by induction of immune tolerance Public/Granted day:2007-06-21
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