Invention Grant
US07718780B2 Preparation of monoclonal antibody to N-myc downstream regulated gene 2 and determination of NDRG2 using protein chip
有权
制备N-myc下游调控基因2的单克隆抗体，并使用蛋白芯片测定NDRG2
- Patent Title: Preparation of monoclonal antibody to N-myc downstream regulated gene 2 and determination of NDRG2 using protein chip
- Patent Title (中): 制备N-myc下游调控基因2的单克隆抗体，并使用蛋白芯片测定NDRG2
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Application No.: US11393897Application Date: 2006-03-31
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Publication No.: US07718780B2Publication Date: 2010-05-18
- Inventor: Eun Young Song , Jae Wha Kim , Hee Gu Lee , Jong Seok Lim , Seung Chul Choi , Mi Young Cho , Kyoung Eun Baek , Jin Sook Kim , Jong Tae Kim , Do Young Yoon , Dur Han Kwon , Mi-Young Park , Young Il Yeom , Yong-Kyung Choe , Young-Jun Kim
- Applicant: Eun Young Song , Jae Wha Kim , Hee Gu Lee , Jong Seok Lim , Seung Chul Choi , Mi Young Cho , Kyoung Eun Baek , Jin Sook Kim , Jong Tae Kim , Do Young Yoon , Dur Han Kwon , Mi-Young Park , Young Il Yeom , Yong-Kyung Choe , Young-Jun Kim
- Applicant Address: KR Daejeon
- Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee: Korea Research Institute of Bioscience and Biotechnology
- Current Assignee Address: KR Daejeon
- Priority: KR10-2005-0118140 20051206
- Main IPC: C12P21/08
- IPC: C12P21/08 ; C07K16/00 ; C12N5/06 ; C12N5/16
Abstract:
The present invention relates to a monoclonal antibody specific for N-myc downstream regulated gene 2 (NDRG 2) protein, a cell line producing the monoclonal antibody, a method for measuring a quantity and quality of NDRG 2 protein, and a protein chip using the same. In the present invention, NDRG 2, a cancer-related factor is specifically expressed in dendritic cells differentiated from a monocyte of human peripheral blood. Accordingly, the monoclonal antibody specific for the NDRG 2 protein, the protein chip comprising the same and the method for measuring a quantity and quality of the NDRG 2 protein by using the same can be applied to elucidate characteristics of the dendritic cell and perform a research on the NDRG 2. Therefore, the present invention may help clinically to investigate and treat intractable diseases and cancers using the dendritic cell.
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