Invention Grant
US07718795B2 Succinoylamino benzodiazepines as inhibitors of aβ protein production
失效
琥珀酰氨基苯并二氮杂作为抑制剂 蛋白质生产
- Patent Title: Succinoylamino benzodiazepines as inhibitors of aβ protein production
- Patent Title (中): 琥珀酰氨基苯并二氮杂作为抑制剂 蛋白质生产
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Application No.: US12061227Application Date: 2008-04-02
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Publication No.: US07718795B2Publication Date: 2010-05-18
- Inventor: Richard E. Olson
- Applicant: Richard E. Olson
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Pharma Company
- Current Assignee: Bristol-Myers Squibb Pharma Company
- Current Assignee Address: US NJ Princeton
- Agent Gary D. Greenblatt
- Main IPC: C07D243/12
- IPC: C07D243/12 ; C07D243/14
Abstract:
This invention relates to novel lactams having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
Public/Granted literature
- US20080207602A1 SUCCINOYLAMINO BENZODIAZEPINES AS INHIBITORS OF ABETA PROTEIN PRODUCTION Public/Granted day:2008-08-28
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