Systems and methods using network interface card-based (NIC-based) prefetching for host TCP context lookup are disclosed. The process generally includes hashing, by the NIC, a packet received over the network, computing a host hash table cache line in a host memory using the hash value and using a hash table pages table containing host memory physical page addresses of a host hash table, and computing a host context table cache line in a host memory using the hash value and using a context table pages table containing host memory physical page addresses of a host context table. The NIC may be initialized with the hash table pages table and the context table pages table as well as with the a set number of hash node entries in the hash table of the host memory.