A method of operation of a computer system having a master and slave Inter-IC (I2C) bus network includes detecting and isolating an I2C bus failure, configuring a failed I2C bus as offline, reconfiguring a remaining I2C bus as a multi-mastered bus, and masking the failed I2C bus from operation until the failed I2C bus can be repaired. A first test request is sent to a remote device from a local device. If the remote device receives the first test request, a remote bus mode is switched to a failure position, a local bus mode is switched to a multi-master position, and a second request is sent to the remote device to indicate position changes.