System and method for performing distributed input/output (I/O). A distributed I/O device (the device) coupled to a controller may read data from a serial port, may determine if the data are framed by time, and if so, may handle the data according to a time-based protocol. If the data are not framed by time, the device may determine if the data are framed by delimiters, and if so, may determine an appropriate delimiter-based protocol for the data from a plurality of delimiter-based protocols, and handle the data according to the appropriate delimiter-based protocol. This process may be repeated in an iterative manner to read a stream of data from the serial port. The device may include or be coupled to one or more I/O modules (e.g., for DAQ, motion control, etc.), which themselves may be coupled to a unit under test or other external device or phenomenon via additional devices.