A system for treatment of cyclo deviation of one or both eyes of a patient and related methods are disclosed. The system for treatment of cyclo deviation may include eyeglasses with lenses and a frame wherein at least one of the lenses is a prism. The prism may be disposed such that a primary plane of the prism does not lie perpendicular to the primary gaze of the patient. The prism may be rotated such that it is not co-planar with the other lens of the eyeglasses. For example, the prism may be oriented in a base-out configuration and also be tilted in a pantoscopic (e.g., top out) or retroscopic (e.g., bottom out) manner.