Invention Grant
US07727518B2 Method of using IL-29 cysteine mutant to treat hepatitis C and hepatitis B
有权
使用IL-29半胱氨酸突变体治疗丙型肝炎和乙型肝炎的方法
- Patent Title: Method of using IL-29 cysteine mutant to treat hepatitis C and hepatitis B
- Patent Title (中): 使用IL-29半胱氨酸突变体治疗丙型肝炎和乙型肝炎的方法
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Application No.: US12043885Application Date: 2008-03-06
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Publication No.: US07727518B2Publication Date: 2010-06-01
- Inventor: Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
- Applicant: Lowell J. Brady , Kevin M. Klucher , Chung Chan , Dennis L. Dong , Hong Y. Liu , Paul O. Sheppard , Thomas R. Bukowski
- Applicant Address: US TN Nashville
- Assignee: ZymoGenetics, LLC
- Current Assignee: ZymoGenetics, LLC
- Current Assignee Address: US TN Nashville
- Agent Brian J. Walsh
- Main IPC: A61K38/19
- IPC: A61K38/19 ; A61K45/00
Abstract:
Homogeneous preparations of IL-28A, IL-28B, and IL-29 have been produced by mutating one or more of the cysteine residues in the polynucleotide sequences encoding the mature proteins. The cysteine mutant proteins can be shown to either bind to their cognate receptor or exhibit biological activity. One type of biological activity that is shown is an antiviral activity.
Public/Granted literature
- US20080279816A1 HOMOGENEOUS PREPARATIONS OF IL-28 AND IL-29 Public/Granted day:2008-11-13
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