Invention Grant
US07727531B2 Antibodies for preventing and treating attaching and effacing Escherichia coli (AEEC) associated diseases
有权
用于预防和治疗附着和消除大肠杆菌（AEEC）相关疾病的抗体
- Patent Title: Antibodies for preventing and treating attaching and effacing Escherichia coli (AEEC) associated diseases
- Patent Title (中): 用于预防和治疗附着和消除大肠杆菌（AEEC）相关疾病的抗体
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Application No.: US12257420Application Date: 2008-10-24
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Publication No.: US07727531B2Publication Date: 2010-06-01
- Inventor: John M. Fairbrother , Josée Harel , Isabelle Batisson , Francis Girard , Marie-Pierre Guimond
- Applicant: John M. Fairbrother , Josée Harel , Isabelle Batisson , Francis Girard , Marie-Pierre Guimond
- Applicant Address: CA Quebec
- Assignee: Valorisation-Recherche, Societe En commandite
- Current Assignee: Valorisation-Recherche, Societe En commandite
- Current Assignee Address: CA Quebec
- Agency: Myers Bigel Sibley & Sajovec P.A.
- Priority: CA2339436 20010315
- Main IPC: A61K39/395
- IPC: A61K39/395
Abstract:
The present invention relates to antibodies immunologically specific for an attaching and effacing Escherichia coli (AEEC) virulence-associated protein, products, compositions and methods and to their use thereof in the prevention of an AEEC infection in a mammal. The antibody of the invention is immunologically specific for an AEEC virulence-associated protein and is capable of preventing an in vivo AEEC intestinal infection when administered to a mammal. The antibody of the invention is preferably useful for preventing the development of A/E intestinal lesions associated with the AEEC. This is achieved by preferably using IgY antibodies immunologically specific for one or more AEEC virulence-associated proteins, such as Eae, Tir, EspA and Paa.
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