Invention Grant
- Patent Title: Oral preparations with favorable disintegration characteristics
- Patent Title (中): 口服制剂具有良好的分解特性
-
Application No.: US10381036Application Date: 2001-09-14
-
Publication No.: US07727553B2Publication Date: 2010-06-01
- Inventor: Kazuyuki Fujihara
- Applicant: Kazuyuki Fujihara
- Applicant Address: JP Osaka-Shi, Osaka
- Assignee: Dainippon Sumitomo Pharma Co., Ltd.
- Current Assignee: Dainippon Sumitomo Pharma Co., Ltd.
- Current Assignee Address: JP Osaka-Shi, Osaka
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP2000-288234 20000922
- International Application: PCT/JP01/07983 WO 20010914
- International Announcement: WO02/24166 WO 20020328
- Main IPC: A61K9/14
- IPC: A61K9/14

Abstract:
The present invention provides oral preparations with good disintegration containing a slightly water-soluble active ingredient, which comprise a mixture of a solid formed product (e.g. a granule) and a second disintegrant wherein said solid formed product comprises a slightly water-soluble active ingredient, a first disintegrant and a water-soluble excipient which is formed by using a water-soluble polymer binder; or comprises a solid formed product prepared from a slightly water-soluble active ingredient, a disintegrant and a sugar alcohol by using a water-soluble polymer binder. When orally administered, these oral preparations exhibit excellent dissolution characteristics of the active ingredient in the digestive tract, and further, these preparations can show equivalent dissolution profile even at different amounts of the active ingredient, and thus enable the selection of the most suitable medicament for each patient, which makes these preparations highly useful in the clinical field.
Public/Granted literature
- US20040028741A1 Oral preparations with favorable disintegration characteristics Public/Granted day:2004-02-12
Information query