Invention Grant
- Patent Title: Method for stabilizing a cryoprecipitate of plasmatic proteins for being subjected to a viral inactivation thermal treatment
- Patent Title (中): 稳定血浆蛋白的冷沉淀物进行病毒灭活热处理的方法
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Application No.: US10563620Application Date: 2004-07-08
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Publication No.: US07727743B2Publication Date: 2010-06-01
- Inventor: Annie Bardat , Edith Begin
- Applicant: Annie Bardat , Edith Begin
- Applicant Address: FR Les Ulis
- Assignee: Laboratoire Francais du Fractionnement et des Biotechnologies
- Current Assignee: Laboratoire Francais du Fractionnement et des Biotechnologies
- Current Assignee Address: FR Les Ulis
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: FR0308403 20030709
- International Application: PCT/FR2004/001788 WO 20040708
- International Announcement: WO2005/004901 WO 20050120
- Main IPC: C12P21/04
- IPC: C12P21/04
Abstract:
The invention relates to a method for obtaining cryoprecipitatable proteins, comprising a viral inactivation step by thermally treating a lyophilisate of these proteins, comprising, before rendering the proteins in the form of a lyophilisate, an initial addition step, to these proteins, of a stabilizing and solubilizing formulation containing a mixture consisting of arginine, at least one hydrophobic amino acid and of tribasic sodium citrate. The invention also relates to a concentrate consisting of at least one cryoprecipitable protein containing the stabilizing and solubilizing formulation introduced according to the method and being suited for therapeutic use.
Public/Granted literature
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