Invention Grant
US07727749B2 Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids
有权
脂肪族二腈的立体选择性生物转化为氰基羧酸
- Patent Title: Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids
- Patent Title (中): 脂肪族二腈的立体选择性生物转化为氰基羧酸
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Application No.: US10599899Application Date: 2005-04-01
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Publication No.: US07727749B2Publication Date: 2010-06-01
- Inventor: Michael P. Burns , Justin K. Weaver , John Wing Wong
- Applicant: Michael P. Burns , Justin K. Weaver , John Wing Wong
- Applicant Address: US NY New York
- Assignee: Pfizer, Inc.
- Current Assignee: Pfizer, Inc.
- Current Assignee Address: US NY New York
- Agent Jennifer A. Kispert; B. Timothy Creagan
- International Application: PCT/IB2005/000873 WO 20050401
- International Announcement: WO2005/100580 WO 20051027
- Main IPC: C12P13/04
- IPC: C12P13/04 ; C12P13/00 ; C07C205/00
Abstract:
The present invention is directed to a regio- and stereoselective bioconversion of selected aliphatic dinitriles into corresponding cyanocarboxylic acids. More particularly, the present invention provides methods for the conversion of 2-isobutyl-succinonitrile into (S)-3 cyano-5-methylhexanoic acid, which is a useful intermediate in the synthesis of (S)-3(aminomethyl)-5-methylhexanoic acid (pregabalin). Pregabalin can be used for treating certain cerebral diseases, for example, in the treatment and prevention of seizure disorders, pain, and psychotic disorders.
Public/Granted literature
- US20070196905A1 Stereoselective bioconversion of aliphatic dinitriles into cyano carboxylic acids Public/Granted day:2007-08-23
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