Invention Grant
- Patent Title: Peptidomimetic inhibitors of post-proline cleaving enzymes
- Patent Title (中): 后脯氨酸切割酶的肽模拟抑制剂
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Application No.: US10496706Application Date: 2002-11-26
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Publication No.: US07727964B2Publication Date: 2010-06-01
- Inventor: William W. Bachovchin
- Applicant: William W. Bachovchin
- Applicant Address: US MA Medford
- Assignee: Trustees of Tufts College
- Current Assignee: Trustees of Tufts College
- Current Assignee Address: US MA Medford
- Agency: Foley Hoag LLP
- Agent Dana M. Gordon
- International Application: PCT/US02/38053 WO 20021126
- International Announcement: WO03/045977 WO 20030605
- Main IPC: A61K38/05
- IPC: A61K38/05 ; A61K31/195 ; A61K31/69 ; C07K5/065 ; C07K5/068 ; C07K5/072 ; C07K5/06 ; C07C233/00 ; C07C235/00 ; C07C237/00 ; C07C231/00 ; C07C231/02 ; C07C231/08
Abstract:
The present invention relates to inhibitors of post-proline cleaving enzymes, such as inhibitors of dipeptidyl peptidase IV, as well as pharmaceutical compositions thereof, and methods for using such inhibitors. In particular, the inhibitors of the present invention are improved over those in the prior art by selection of particular classes of sidechains in the P1 and/or P2 position of the inhibitor. The compounds of the present invention can have a better therapeutic index, owing in part to reduced toxicity and/or improved specificity for the targeted protease.
Public/Granted literature
- US20050070482A1 Peptidomimetic inhibitors of post-proline cleaving enzymes Public/Granted day:2005-03-31
Information query
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