Invention Grant
US07727969B2 Controlled release nanoparticle having bound oligonucleotide for targeted delivery
有权
具有用于靶向递送的结合寡核苷酸的受控释放纳米颗粒
- Patent Title: Controlled release nanoparticle having bound oligonucleotide for targeted delivery
- Patent Title (中): 具有用于靶向递送的结合寡核苷酸的受控释放纳米颗粒
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Application No.: US10456978Application Date: 2003-06-06
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Publication No.: US07727969B2Publication Date: 2010-06-01
- Inventor: Omid C. Farokhzad , Sang Yong Jon , Robert S. Langer
- Applicant: Omid C. Farokhzad , Sang Yong Jon , Robert S. Langer
- Applicant Address: US MA Cambridge
- Assignee: Massachusetts Institute of Technology
- Current Assignee: Massachusetts Institute of Technology
- Current Assignee Address: US MA Cambridge
- Agency: Lahive & Cockfield, LLP
- Agent Brian C. Trinque
- Main IPC: A61K31/7088
- IPC: A61K31/7088 ; A61K9/14 ; C12Q1/68 ; C12N11/08 ; C12N11/04 ; G01N33/545 ; G01N33/549 ; A61K38/00 ; C07K17/04 ; C07K17/08
Abstract:
The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods of treatment using the conjugate. The controlled release polymer system includes an agent such as a therapeutic, diagnostic, prognostic, or prophylactic agent. The nucleic acid ligand that is bound to the controlled release polymer system, binds selectively to a target, such as a cell surface antigen, and thereby delivers the controlled release polymer system to the target.
Public/Granted literature
- US20040247680A1 Targeted delivery of controlled release polymer systems Public/Granted day:2004-12-09
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