Invention Grant
- Patent Title: Beta-carbolines useful for treating inflammatory disease
- Patent Title (中): β-咔啉可用于治疗炎性疾病
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Application No.: US10821545Application Date: 2004-04-09
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Publication No.: US07727985B2Publication Date: 2010-06-01
- Inventor: Michael E. Hepperle , Julie Fields Liu , Francois Soucy , Yingchun Ye , Robert S. Murray , Raman Prakash , Jeremy D. Little , Alfredo Castro , Hormoz Mazdiyasni , Paul E. Fleming , Dominic Reynolds
- Applicant: Michael E. Hepperle , Julie Fields Liu , Francois Soucy , Yingchun Ye , Robert S. Murray , Raman Prakash , Jeremy D. Little , Alfredo Castro , Hormoz Mazdiyasni , Paul E. Fleming , Dominic Reynolds
- Applicant Address: US MA Cambridge
- Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Millennium Pharmaceuticals, Inc.
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; C07D413/14 ; C07D413/02
Abstract:
This invention provides beta-carboline compounds of formula I: wherein Ring A is a substituted pyridinyl, pyrimidinyl, morpholinyl, piperidinyl, piperazinyl, pyrrolidinyl, pyranyl, tetrahydrofuranyl, cyclohexyl, cyclopentyl or thiomorpholinyl ring and R1, R2 and R3 are as described in the specification. The compounds are IKK-2 inhibitors that are useful for treating IKK-2-mediated diseases such as inflammatory diseases and cancer.
Public/Granted literature
- US20040235839A1 Beta-carbolines useful for treating inflammatory disease Public/Granted day:2004-11-25
Information query
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