Invention Grant
US07728014B2 Heteroaromatic compounds having sphingosine-1-phosphate (S1P) receptor agonist biological activity
有权
具有鞘氨醇-1-磷酸（S1P）受体激动剂生物活性的杂芳族化合物
- Patent Title: Heteroaromatic compounds having sphingosine-1-phosphate (S1P) receptor agonist biological activity
- Patent Title (中): 具有鞘氨醇-1-磷酸（S1P）受体激动剂生物活性的杂芳族化合物
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Application No.: US11850756Application Date: 2007-09-06
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Publication No.: US07728014B2Publication Date: 2010-06-01
- Inventor: Richard L. Beard , John E. Donello , Haiqing Yuan , Xiaoxia Liu
- Applicant: Richard L. Beard , John E. Donello , Haiqing Yuan , Xiaoxia Liu
- Applicant Address: unknown Irvine
- Assignee: Allergan, Inc.
- Current Assignee: Allergan, Inc.
- Current Assignee Address: unknown Irvine
- Agency: Allergan, Inc.
- Agent Kevin J. Forrestal; John E. Wurst
- Main IPC: C07D213/04
- IPC: C07D213/04 ; A61K31/44 ; A61P37/00 ; A61P31/00
Abstract:
A novel compound having agonist activity at the S1P3 receptor which is represented by the formula I wherein X is selected from the group consisting of CR3, N and NO; Y is selected from the group consisting of CR3, N and NO; Z is selected from the group consisting of CR3, N and NO; and at least one of X, Y and Z is N or NO; V is O or NOR4 R1 is an aryl group; R2 is an aryl group; R3 is selected from the group consisting of H and alkyl; and 2 of said R3 groups may together form a cyclic alkyl ring having from 3 to 6 carbon atoms; R4 is selected from the group consisting of H and alkyl; a is 0 or an integer of from 1 to 6; b is 0 or 1; c is 0 or 1; f is 0 or an integer of 1 or 2; x is 0 or 1; y is 0 or an integer of from 1 to 3; and z is 0 or an integer of from 1 to 3.
Public/Granted literature
- US20080064872A1 HETEROAROMATIC COMPOUNDS HAVING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR AGONIST BIOLOGICAL ACTIVITY Public/Granted day:2008-03-13
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