Invention Grant
- Patent Title: Process for the preparation of Valsartan and precursors thereof
- Patent Title (中): 制备缬沙坦及其前体的方法
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Application No.: US11568054Application Date: 2005-04-18
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Publication No.: US07728021B2Publication Date: 2010-06-01
- Inventor: Pere Dalmases Barjoan , Jordi Bessa Belmunt , Joan Huguet Clotet , Juan Antonio Perez Andres
- Applicant: Pere Dalmases Barjoan , Jordi Bessa Belmunt , Joan Huguet Clotet , Juan Antonio Perez Andres
- Applicant Address: ES Castellbisbal
- Assignee: INKE, S.A.
- Current Assignee: INKE, S.A.
- Current Assignee Address: ES Castellbisbal
- Agent Cozen O'Connor
- Priority: ES200400949 20040420
- International Application: PCT/IB2005/001100 WO 20050418
- International Announcement: WO2005/102987 WO 20051103
- Main IPC: A61K31/41
- IPC: A61K31/41 ; C07D257/00

Abstract:
This invention relates to a process for preparing intermediates useful in preparing Valsartan and to a process for preparing the latter, together with synthesis intermediates of formula (IV), (V) and (VI), useful for manufacturing a medicament for the treatment of arterial hypertension or heart failure. The process for preparing Valsartan permits it to be prepared on an industrial scale with high yields and without racemisation problems, in addition to using simple and available starting products. The invention also provides a process for preparing the intermediate of formula (VI), from an intermediate of formula (V) that does not require protection of the carboxylic acid prior to N-acylation.
Public/Granted literature
- US20090221836A1 PROCESS FOR THE PREPARATION OF VALSARTAN AND PRECURSORS THEREOF Public/Granted day:2009-09-03
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