Invention Grant
- Patent Title: Ester derivatives of rhein and their therapeutic use
- Patent Title (中): 大黄酸的酯衍生物及其治疗用途
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Application No.: US10591157Application Date: 2005-03-04
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Publication No.: US07728035B2Publication Date: 2010-06-01
- Inventor: Andrew Douglas Baxter , Andrea Walmsley
- Applicant: Andrew Douglas Baxter , Andrea Walmsley
- Applicant Address: GB Essex
- Assignee: Sosei R&D Ltd.
- Current Assignee: Sosei R&D Ltd.
- Current Assignee Address: GB Essex
- Agency: Saliwanchik, Lloyd & Saliwanchik
- Priority: GB0404953.2 20040304
- International Application: PCT/GB2005/000832 WO 20050304
- International Announcement: WO2005/085170 WO 20050915
- Main IPC: A61K31/21
- IPC: A61K31/21 ; C07C49/593

Abstract:
Compounds that may have anti-inflammatory activity are of general formula (I); wherein X1, is H or COR1, and X2 is H or COR2 but X1, and X2 are not both H; R1 and R2 are the same or different and are each C1-4 alkyl substituted with R3, or a four to seven-membered ring which can be optionally substituted with R8 and can contain one or more additional heteroatoms selected from O, S(O)n and NR9; is R3 is F, CF3, OR4, NR5R6 O, S(O)n R7; R4, R5 and R6 are the same or different and are each H or C1-4 alkyl optionally substituted with R3, or NR5R6 is a C4-6 heterocycloalkyl ring containing one or more heteroatoms selected from O, NR8 and S(O)n; each n is 0-2; R7 is C1-4 alkyl; R8 is as defined for R3 or C1-4 alkyl optionally substituted with R3 or halogen; and R9 is H or C1-4 alkyl; or a salt, solvate or hydrate thereof.
Public/Granted literature
- US20070185036A1 Ester derivatives of rhein and their therapeutic use Public/Granted day:2007-08-09
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