Invention Grant
- Patent Title: Method for monitoring collagen type II degradation in cartilage
- Patent Title (中): 监测软骨II型胶原蛋白降解的方法
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Application No.: US12222352Application Date: 2008-08-07
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Publication No.: US07728112B2Publication Date: 2010-06-01
- Inventor: Jean-Yves Reginster , Michelle Deberg , Yves Henrotin , Stephan Christgau
- Applicant: Jean-Yves Reginster , Michelle Deberg , Yves Henrotin , Stephan Christgau
- Applicant Address: BE Liege
- Assignee: Universite de Liege
- Current Assignee: Universite de Liege
- Current Assignee Address: BE Liege
- Agency: Jacobson Holman PLLC
- Priority: DK200200380 20020313
- Main IPC: C07K16/18
- IPC: C07K16/18 ; G01N33/53 ; G01N33/543
Abstract:
A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most mammals utilizes an immunoassay to detect fragments of collagen type II resulting from collagenase activity comprising an antibody directed against an epitope comprised in the amino acid sequence HRGYPGLDG (SEQ ID NO:1), located in the helical region of collagen type II.
Public/Granted literature
- US20090042220A1 Method for monitoring collagen type II degradation in cartilage Public/Granted day:2009-02-12
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