Invention Grant
US07728115B2 Compositions and methods useful for the diagnosis and treatment of heparin induced thrombocytopenia/thrombosis
有权
用于肝素诱导的血小板减少/血栓形成的诊断和治疗的组合物和方法
- Patent Title: Compositions and methods useful for the diagnosis and treatment of heparin induced thrombocytopenia/thrombosis
- Patent Title (中): 用于肝素诱导的血小板减少/血栓形成的诊断和治疗的组合物和方法
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Application No.: US11195095Application Date: 2005-08-02
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Publication No.: US07728115B2Publication Date: 2010-06-01
- Inventor: Gowthami M. Arepally , Walter Kisiel , Keiko Kamei , Shintaro Kamei
- Applicant: Gowthami M. Arepally , Walter Kisiel , Keiko Kamei , Shintaro Kamei
- Applicant Address: US NM Albuquerque
- Assignee: STC. UNM
- Current Assignee: STC. UNM
- Current Assignee Address: US NM Albuquerque
- Agency: Mueting Raasch & Gebhardt, P.A.
- Main IPC: C07K16/18
- IPC: C07K16/18 ; C12P21/08 ; G01N33/564 ; G01N33/577 ; C12N5/20
Abstract:
The invention includes compositions, kits and methods comprising a monoclonal antibody which shares key functional properties with the polyclonal antibodies which participate in the pathogenesis of heparin induced thrombocytopenia/thrombosis (HIT/HITT) in a mammal. The monoclonal antibody of the invention preferentially binds with a PF4/heparin complex relative to the binding of the antibody with PF4 or heparin alone. The monoclonal antibody of the invention also binds specifically with PF4 in a complex with other glycosaminoglycans besides heparin, and also activates platelets. The monoclonal antibody of the invention is useful in methods for diagnosing and treating HIT/HITT in a mammal. A humanized version of the monoclonal antibody of the invention is also included, along with a process for humanizing the monoclonal antibody of the invention.
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