Invention Grant
- Patent Title: Detomidine hydrochloride crystallization method
- Patent Title (中): 盐酸地西铵结晶法
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Application No.: US11911181Application Date: 2006-04-13
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Publication No.: US07728147B2Publication Date: 2010-06-01
- Inventor: Arto Karjalainen , Seppo Parhi
- Applicant: Arto Karjalainen , Seppo Parhi
- Applicant Address: FI Espoo
- Assignee: Orion Corporation
- Current Assignee: Orion Corporation
- Current Assignee Address: FI Espoo
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: FI20050391 20050415
- International Application: PCT/FI2006/000113 WO 20060413
- International Announcement: WO2006/108910 WO 20061019
- Main IPC: C07D233/58
- IPC: C07D233/58
Abstract:
A method of isolating detomidine (I) hydrochloride as a crystalline salt is provided. The method comprises hydrogenating in the presence of a catalyst of compound of formula (II) in aqueous solution comprising hydrochloric acid, concentrating the solution by distillation, optionally adding hydrochloric acid to the concentrated solution, cooling the concentrated solution and recovering the crystallized detomidine hydrochloride. The product can be recovered directly from aqueous solution with
Public/Granted literature
- US20080287685A1 Detomidine Hydrochloride Crystallization Method Public/Granted day:2008-11-20
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