Invention Grant
- Patent Title: Acyclic oximyl hepatitis C protease inhibitors
- Patent Title (中): 非环氧乙酰丙型肝炎蛋白酶抑制剂
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Application No.: US11758901Application Date: 2007-06-06
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Publication No.: US07728148B2Publication Date: 2010-06-01
- Inventor: Ying Sun , Yat Sun Or , Zhe Wang
- Applicant: Ying Sun , Yat Sun Or , Zhe Wang
- Applicant Address: US MA Watertown
- Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee: Enanta Pharmaceuticals, Inc.
- Current Assignee Address: US MA Watertown
- Agency: Elmore Patent Law Group, P.C.
- Agent Roy P. Issac; Carolyn S. Elmore
- Main IPC: C07D207/00
- IPC: C07D207/00 ; C07D295/00

Abstract:
The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.
Public/Granted literature
- US20080125444A1 ACYCLIC OXIMYL HEPATITIS C PROTEASE INHIBITORS Public/Granted day:2008-05-29
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