Embodiments of the present invention include a system and method of dynamic space-frequency-division multiple-access for the uplink from terminals to a base-station. The system includes a base-station and multiple terminals. According to different spatial mapping modes, the base-station performs an optimization computation using an optimization function in order to obtain control information for controlling terminals; after receiving the control information, the user terminal controls the transmitting mode using this control information. The method includes the following operations: at the base-station, performing an optimization computation using an optimization function according to different spatial mapping modes respectively, in order to obtain control information for controlling terminals; at the user terminal, controlling a transmitting mode using the control information after receiving the above control information. An embodiment of the present invention can achieve a higher system capacity by balancing resource allocation among different users in a domain of transmission power, bandwidth and spatial channels.