A system and method for amplifying cellular signals and reducing interference introduced into a cellular network by the network amplifiers. The network amplifier includes an antenna configured to receive a downlink signal from a base station and a variable gain module for amplifying an uplink signal received from a handset. The variable gain module applies an amplification factor to the uplink signal to generate an adjusted uplink signal to be transmitted to the base station via the antenna. A processor is used for determining a value of the amplification factor, where the value of the amplification factor is a function of a level of the downlink signal. The amplification factor may be selected so that interference introduced into a cellular network by the transmission of the adjusted uplink signal is substantially eliminated.