Invention Grant
US07731971B2 Enhanced CTL epitope-containing HIV-1 reverse transcriptase polypeptides
失效
增强的含CTL表位的HIV-1逆转录酶多肽
- Patent Title: Enhanced CTL epitope-containing HIV-1 reverse transcriptase polypeptides
- Patent Title (中): 增强的含CTL表位的HIV-1逆转录酶多肽
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Application No.: US10551405Application Date: 2004-03-29
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Publication No.: US07731971B2Publication Date: 2010-06-08
- Inventor: Jay A. Berzofsky , Takahiro Okazaki
- Applicant: Jay A. Berzofsky , Takahiro Okazaki
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Townsend and Townsend and Crew LLP
- International Application: PCT/US2004/009617 WO 20040329
- International Announcement: WO2004/092201 WO 20041028
- Main IPC: A61K39/21
- IPC: A61K39/21
Abstract:
The present invention provides peptides and proteins for use in second generation HIV vaccines and as diagnostic tools in the treatment and control of HIV infection. The antiviral protection shown by compositions of the present invention has not been previously achieved with an HLA epitope-enhanced vaccine. These findings define a critical balance between MHC affinity and receptor crossreactivity required for effective epitope enhancement and also demonstrate construction and efficacy of such a component of a new generation vaccine.
Public/Granted literature
- US20060188884A1 Enhanced hiv-1 vaccines and methods for their use Public/Granted day:2006-08-24
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