Invention Grant
- Patent Title: Mutant vesicular stomatitis viruses and uses thereof
- Patent Title (中): 突变型水泡性口炎病毒及其用途
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Application No.: US10551103Application Date: 2004-03-29
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Publication No.: US07731974B2Publication Date: 2010-06-08
- Inventor: John C. Bell , Brian D. Lichty , David F. Stojdl
- Applicant: John C. Bell , Brian D. Lichty , David F. Stojdl
- Applicant Address: CA Ottawa, Ontario US MD Gaithersburg
- Assignee: Ottawa Hospital Research Institute,Wellstat Biologics Corporation
- Current Assignee: Ottawa Hospital Research Institute,Wellstat Biologics Corporation
- Current Assignee Address: CA Ottawa, Ontario US MD Gaithersburg
- Agent Douglas A. Golightly; Lewis J. Kreisler
- International Application: PCT/CA2004/000460 WO 20040329
- International Announcement: WO2004/085658 WO 20041007
- Main IPC: A61K39/205
- IPC: A61K39/205 ; A61K35/76 ; C12N7/00 ; C12N7/01 ; C12N15/47 ; C12N15/86
Abstract:
The present invention provides mutant viruses with a decreased ability to block nuclear transport of mRNA or protein in an infected cell which are attenuated in vivo. The mutant viruses of the present invention may also be capable of triggering the anti-viral systems of normal host cells while remaining sensitive to the effects of these systems. The present invention further provides for the use of the mutant viruses in a range of applications including, but not limited to, as therapeutics for the treatment of cancer and infections, as vaccines and adjuvants, as viral vectors, and as oncolytic and cytolytic agents for the selective lysis of malignant or infected cells.
Public/Granted literature
- US20070098743A1 Mutant vesicular stomatitis viruses and uses thereof Public/Granted day:2007-05-03
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