Invention Grant
US07731995B2 Methods for using soy peptides to inhibit H3 acetylation, reduce expression of HMG CoA reductase, and increase LDL receptor and Sp1 expression in a mammal
有权
使用大豆肽抑制H3乙酰化，减少HMG CoA还原酶的表达，增加哺乳动物的LDL受体和Sp1表达的方法
- Patent Title: Methods for using soy peptides to inhibit H3 acetylation, reduce expression of HMG CoA reductase, and increase LDL receptor and Sp1 expression in a mammal
- Patent Title (中): 使用大豆肽抑制H3乙酰化，减少HMG CoA还原酶的表达，增加哺乳动物的LDL受体和Sp1表达的方法
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Application No.: US11532528Application Date: 2006-09-16
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Publication No.: US07731995B2Publication Date: 2010-06-08
- Inventor: Alfredo Flores Galvez
- Applicant: Alfredo Flores Galvez
- Agent Kathryn P. Wilke
- Main IPC: A61K36/48
- IPC: A61K36/48 ; A62K38/00 ; A61K51/00 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00
Abstract:
Controlled studies demonstrate that methods using soy related peptides inhibit H3 acetylation, reduce expression of HMG CoA reductase and increase LDL receptor and Sp1 expression in mammals. The present disclosure is generally directed to using lunasin peptides and/or lunasin peptide derivatives to 1) inhibit H3 acetylation, 2) reduce expression of HMG CoA reductase, 3) increase LDL receptor expression or 4) increase Sp1 expression in a mammal. In at least one exemplary embodiment of the present disclosure, an effective amount of lunasin peptides or lunasin peptide derivatives and one or more enzyme inhibitors is provided to a mammal to 1) inhibit H3 acetylation, 2) reduce expression of HMG CoA reductase, 3) increase LDL receptor expression or 4) increase Sp1 expression in a mammal.
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